원광대학교병원

관절류마티스내과

이명수

류마티스관절염, 퇴행성관절염, 통풍성관절염, 만성근육통, 신경통, 골다공증 루프스, 베체트씨병, 강직성척추염

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학력/경력

  • 전북대학교 의학과 (박사)
  • 원광대학교 의학과 의학(석사)
  • 원광대학교 의학과 (학사)

학회활동

  • 16th Asia Pacific League of Associations for Rheumatology Congress / Genipin inhibits RANKL-induced osteoclast differentiation / 필리핀 / 20140403
  • Annual European Congress of Rheumatology EULAR 2012 / The specific role of glutaredoxin2 isoform B (GLRX2B) in rankl-induced osteoclastogenesis through activation of the p38-MAPK signal pathway / 독일 / 20120606
  • 대한류마티스학회 추계학술대회 / Targeted therapiesin osteoarthritis: beyond analgesics / 대한민국 / 20101119
  • 2010년 류마티스분과 관리위원회 6월 연수강좌 / Current update of the role of anti-CCP antibody / 대한민국 / 20100626
  • Annual European Congress of Rheumatology EULAR 2010 / INHIBITORY EFFECTS OF IL-3 ON OSTEOCLAST DIFFERENTIATION RELATED WITH ID EXPRESSION / 이탈리아 / 20100619
  • Annual European Congress of Rheumatology EULAR 2010 / REDUCTION OF FUNCTIONALLY SUPPRESSIVE CD4+CE25+ TREGS BY 17 BETA-ESTRADIOL / 이탈리아 / 20100619
  • Annual European Congress of Rheumatology EULAR 2010 / INHIBITORY EFFECTS OF AMORPHOGENIN ON OSTEOCLASTOGENESIS AND LIPOPOLYSACCHARIDE(LPS) INDUCED BONE LOSS / 이탈리아 / 20100617
  • Annual European Congress of Rheumatology EULAR 2010 / IL-17 INCREASES IL-27 EXPRESSION OF BONE MARROW DERIVED DENDRITIC CELLS IN COLLAGEN-INDUCED ARTHRITIS / 이탈리아 / 20100517
  • 제30차 대한 류마티스학회 춘계학술대회 / inhibitory effects of Gastrodia elata Blume on osteoclast differentiation / 대한민국 / 20100514
  • 제 30차 대한 류마티스학회 춘계학술대회 / Inhibitory effects of Amorphigenin on osteoclastogenesis and lipopolysaccharide(LPS) induced bone loss / 대한민국 / 20100514
  • 대한내과학회 류마티스 분과위원회 연수강좌 / New Insights in the Inflammatory Myopathies / 대한민국 / 20090627
  • Annual European Congress of Rheumatology EULAR 2009 / Granulocyte-macrophage colony-stimulating factor regulates fusion of mononuclear osteoclasts into bone-resorbing osteoclasts by a ctivating the RAS/ERK pathway / 덴마크 / 20090612
  • 제29차 대한류마티스학회 춘계학술대회 및 제3차 국제 심포지움 / 전신성 경화증의 초기 발현으로 나타난 기흉 1예 / 대한민국 / 20090515
  • 서울 / Risedronate directly inhibits osteoclastogenesis and inflammatory bone loss2 / 대한민국 / 20080516
  • 서울 / Proteasome inhibitors induce osteoclast survival but suppress bone-resorbing / 대한민국 / 20080516
  • 논문/저서
    • Betulinic Acid Inhibits RANKL-Induced Osteoclastogenesis via Attenuating Akt, NF-kappaB, and PLCγ2-Ca2+ Signaling and Prevents Inflammatory Bone Loss / 공동(제1저자) / JOURNAL OF NATURAL PRODUCTS / AMER CHEMICAL SOC / 202004
    • Neurovascular Behcet's Disease Presenting With Cavernous Sinus Thrombosis: A Rare Case of Assumed Tolosa-Hunt-Like Syndrome / 공동(참여) / ARCHIVES OF RHEUMATOLOGY / TURKISH LEAGUE AGAINST RHEUMATISM / 202003
    • Umbelliferone Prevents Lipopolysaccharide-Induced Bone Loss and Suppresses RANKL-Induced Osteoclastogenesis by Attenuating Akt-c-Fos-NFATc1 Signaling / 공동(교신) / INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES / IVYSPRING INT PUBL / 201909
    • Role of ANTXR1 in the regulation of RANKL-induced osteoclast differentiation and function / 공동(교신) / BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS / ACADEMIC PRESS INC ELSEVIER SCIENCE / 201903
    • Klebsiella Pneumonia-Necrotizing Fasciitis followed by Liver Abscess / 공동(교신) / 한국산학기술학회논문지 / 한국산학기술학회 / 201806
    • Claudin 11 regulates bone homeostasis via bidirectional EphB4-EphrinB2 signaling / 공동(교신) / EXPERIMENTAL AND MOLECULAR MEDICINE / NATURE PUBLISHING GROUP / 201804
    • Hepatic alanine differentiates nonalcoholic steatohepatitis from simple steatosis in humans and mice: A Proton MR spectroscopy study with long echo time / 공동(참여) / J Magn Reson Imaging / J Magn Reson Imaging / 201711
    • Methyl Gallate Inhibits Osteoclast Formation and Function by Suppressing Akt and Btk-PLC gamma 2-Ca2+ Signaling and Prevents Lipopolysaccharide-Induced Bone Loss / 공동(교신) / INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES / MDPI AG / 201703
    • Nicotinamide phosphoribosyltransferase inhibits receptor activator of nuclear factor-kappa B ligand-induced osteoclast differentiation in vitro / 공동(참여) / MOLECULAR MEDICINE REPORTS / SPANDIDOS PUBL LTD / 201702
    • Scattered image artifacts from cone beam computed tomography and its clinical potential in bone mineral density estimation / 공동(참여) / Ko et al. SpringerPlus / Ko et al. SpringerPlus / 201608
    • Efficacy and safety of low-dose tacrolimus for active rheumatoid arthritis with an inadequate response to methotrexate / 공동(참여) / Korean J Intern Med / Korean J Intern Med / 201607
    • Protocatechuic Acid Attenuates Osteoclastogenesis by Downregulating JNK/c-Fos/NFATc1 Signaling and Prevents Inflammatory Bone Loss in Mice / 공동(교신) / PHYTOTHERAPY RESEARCH / WILEY-BLACKWELL / 201604
    • WHI-131 Promotes Osteoblast Differentiation and Prevents Osteoclast Formation and Resorption in Mice / 공동(참여) / JOURNAL OF BONE AND MINERAL RESEARCH / WILEY-BLACKWELL / 201602
    • Ebselen Is a Potential Anti-Osteoporosis Agent by Suppressing Receptor Activator of Nuclear Factor Kappa-B Ligand-Induced Osteoclast Differentiation In vitro and Lipopolysaccharide-Induced Inflammatory Bone Destruction In vivo / 공동(교신) / INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES / IVYSPRING INT PUBL / 201601
    • Development of a novel frontal bone defect mouse model for evaluation of osteogenesis efficiency / 공동(교신) / JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A / WILEY-BLACKWELL / 201512
    • Evaluation of a novel technique for intraperitoneal injections in mice / 공동(교신) / Lab Anim (NY). / Lab Anim (NY). / 201511
    • Massive elimination of multinucleated osteoclasts by eupatilin is due to dual inhibition of transcription and cytoskeletal rearrangement / 공동(참여) / Bone Rep / Bone Rep / 201510
    • CTRP3 acts as a negative regulator of osteoclastogenesis through AMPK-c-Fos-NFATc1 signaling in vitro and RANKL-induced calvarial bone destruction in vivo / 공동(교신) / BONE / ELSEVIER SCIENCE INC / 201510
    • Harpagoside inhibits RANKL-induced osteoclastogenesis via Syk-Btk-PLCγ2-Ca(2+) signaling pathway and prevents inflammation-mediated bone loss / 공동(교신) / J Nat Prod / J Nat Prod / 201509
    • Repositioning Potential of PAK4 to Osteoclastic Bone Resorption / 공동(참여) / J Bone Miner Res / J Bone Miner Res / 201508
    • Overexpression of prohibitin-1 inhibits RANKL-induced activation of p38-Elk-1-SRE signaling axis blocking MKK6 activity / 공동(교신) / Biochem Biophys Res Commun / Biochem Biophys Res Commun / 201508
    • Stauntonia hexaphylla (Lardizabalaceae) leaf methanol extract inhibits osteoclastogenesis and bone resorption activity via proteasome-mediated degradation of c-Fos protein and suppression of NFATc1 expression / 공동(참여) / BMC Complement Altern Med / BMC Complement Altern Med / 201508
    • The Inhibitory Effect of Angelica tenuissima Water Extract on Receptor Activator of Nuclear Factor-Kappa-B Ligand-Induced Osteoclast Differentiation and Bone Resorbing Activity of Mature Osteoclasts / 공동(참여) / Am J Chin Med / Am J Chin Med / 201506
    • Esculetin attenuates receptor activator of nuclear factor kappa-B ligand-mediated osteoclast differentiation through c-Fos/nuclear factor of activated T-cells c1 signaling pathway / 공동(참여) / Biochem Biophys Res Commun / Biochem Biophys Res Commun / 201505
    • Progranulin and a Five Transmembrane Domain-Containing Receptor-like Gene Are the Key Components in Receptor Activator of Nuclear Factor kappa B (RANK)-dependent Formation of Multinucleated Osteoclasts / 공동(교신) / JOURNAL OF BIOLOGICAL CHEMISTRY / AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC / 201501
    • Mollugin from Rubea cordifolia suppresses receptor activator of nuclear factor-kappa B ligand-induced osteoclastogenesis and bone resorbing activity in vitro and prevents lipopolysaccharide-induced bone loss in vivo / 공동(참여) / PHYTOMEDICINE / ELSEVIER GMBH / 201501
    • Purslane suppresses osteoclast differentiation and bone resorbing activity via inhibition of Akt/GSK3β-c-Fos-NFATc1 signaling in vitro and prevents lipopolysaccharide-induced bone loss in vivo / 공동(참여) / Biol. Pharm. Bull / Biol. Pharm. Bull / 201501
    • Osteoclastogenic activity of translationally-controlled tumor protein (TCTP) with reciprocal repression of p21 / 공동(참여) / FEBS LETTERS / ELSEVIER SCIENCE BV / 201411
    • Ampelopsis brevipedunculata Extract Prevents Bone Loss by Inhibiting Osteoclastogenesis in Vitro and in Vivo / 공동(참여) / MOLECULES / MDPI AG / 201411
    • Dual Effect of Chrysanthemum indicum Extract to Stimulate Osteoblast Differentiation and Inhibit Osteoclast Formation and Resorption In Vitro / 공동(교신) / EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE / HINDAWI PUBLISHING CORPORATION / 201411
    • Parthenolide inhibits osteoclast differentiation and bone resorbing activity by down-regulation of NFATc1 induction and c-Fos stability, during RANKL-mediated osteoclastogenesis / 공동(교신) / BMB REPORTS / KOREAN SOCIETY BIOCHEMISTRY MOLECULAR BIOLOGY / 201408
    • Aconitum pseudo-laeve var. erectum Inhibits Receptor Activator of Nuclear Factor Kappa-B Ligand-Induced Osteoclastogenesis via the c-Fos/nuclear Factor of Activated T-Cells, Cytoplasmic 1 Signaling Pathway and Prevents Lipopolysaccharide-Induced Bone Loss in Mice / 공동(교신) / MOLECULES / MDPI AG / 201408
    • Emodin Regulates Bone Remodeling by Inhibiting Osteoclastogenesis and Stimulating Osteoblast Formation / 공동(교신) / JOURNAL OF BONE AND MINERAL RESEARCH / WILEY-BLACKWELL / 201407
    • Micro-CT measurements of tumoral vessels supplied by portal circulation in hepatic colorectal metastasis mouse model / 공동(참여) / Microscopy Research and Technique / Microscopy Research and Technique / 201405
    • 9-Hydroxy-6,7-dimethoxydalbergiquinol inhibits osteoclast differentiation through down-regulation of Akt, c-Fos and NFATc1 / 공동(교신) / INTERNATIONAL IMMUNOPHARMACOLOGY / ELSEVIER SCIENCE BV / 201405
    • Genipin Inhibits RANKL-Induced Osteoclast Differentiation Through Proteasome-Mediated Degradation of c-Fos Protein and Suppression of NF-kappa B Activation / 공동(교신) / JOURNAL OF PHARMACOLOGICAL SCIENCES / JAPANESE PHARMACOLOGICAL SOC / 201403
    • Oleanolic acid acetate inhibits osteoclast differentiation by downregulating PLC gamma 2-Ca2+-NFATc1 signaling, and suppresses bone loss in mice / 공동(교신) / BONE / ELSEVIER SCIENCE INC / 201403
    • (2S)-2 `-Methoxykurarinone Inhibits Osteoclastogenesis and Bone Resorption through Down-Regulation of RANKL Signaling / 공동(교신) / BIOLOGICAL & PHARMACEUTICAL BULLETIN / PHARMACEUTICAL SOC JAPAN / 201402
    • Chlorogenic acid inhibits osteoclast differentiation and bone resorption by down-regulation of receptor activator of nuclear factor kappa-B ligand-induced nuclear factor of activated T cells c1 expression. / 공동(참여) / Biol Pharm Bull / Biol Pharm Bull / 201308
    • Costunolide Inhibits Osteoclast Differentiation by Suppressing c-Fos Transcriptional Activity. / 공동(참여) / Phytotherapy Research / John Wiley & Sons. Inc / 201307
    • MicroRNA-488 regulates zinc transporter SLC39A8/ZIP8 during pathogenesis of osteoarthritis / 공동(교신) / JOURNAL OF BIOMEDICAL SCIENCE / BIOMED CENTRAL LTD / 201305
    • Cyclophosphamide-induced Posterior Reversible Encephalopathy Syndrome in a Patient with Lupus Nephritis / 공동(교신) / 대한류마티스학회지 / 대한류마티스학회 / 201304
    • 한국인 조기 류마티스관절염 환자에서의 2010 ACR/EULAR 분류 기준의 유용성 및 한계 / 공동(참여) / 대한류마티스학회지 / 대한류마티스학회 / 201212
    • Gender Differences in Clinical Features and Anti-TNF Agent Use in Korean Ankylosing Spondylitis Patients / 공동(참여) / 대한류마티스학회지 / 대한류마티스학회 / 201206
    • 파골세포 분화에 복령 추출물이 미치는 영향 / 공동(참여) / 동의생리병리학회지 / 대한동의병리학회 / 201206
    • βig-h3 절편-RGD 재조합단백의 만성염증성 관절염 치료효과 / 단독 / 대한류마티스학회지 / 대한류마티스학회 / 201206
    • Effect of interferon-gamma on the fusion of mononuclear osteoclasts into bone-resorbing osteoclasts / 공동(제1저자) / BMB REPORTS / KOREAN SOCIETY BIOCHEMISTRY MOLECULAR BIOLOGY / 201205
    • Inhibitory regulation of osteoclast differentiation by interleukin-3 via regulation of c-Fos and Id protein expression / 공동(제1저자) / JOURNAL OF CELLULAR PHYSIOLOGY / WILEY-BLACKWELL / 201205
    • 白何首烏 물 추출물의 파골세포 분화에 미치는 영향 / 공동(참여) / 동의생리병리학회지 / 대한동의병리학회 / 201204
    • Glutaredoxin2 isoform b (Glrx2b) promotes RANKL-induced osteoclastogenesis through activation of the p38-MAPK signaling pathway / 공동(교신) / BMB REPORTS / KOREAN SOCIETY BIOCHEMISTRY MOLECULAR BIOLOGY / 201203
    • VapB as a regulator of osteoclastogenesis via modulation of PLC gamma 2-Ca2+-NFAT signaling / 공동(교신) / FEBS LETTERS / ELSEVIER SCIENCE BV / 201202
    • 파골세포 분화에 미치는 蘆會 추출물의 효과 / 공동(참여) / 동의생리병리학회지 / 대한동의병리학회 / 201112
    • Inhibitory Effects of 1′,2′-Dihydrorotenone on Osteoclast Differentiation and Bone Resorption In Vitro and In Vivo / 공동(참여) / 대한체질인류학회지 / 대한체질인류학회 / 201109
    • 파골세포 분화에 미치는 복분자 물 추출물의 효과 / 공동(참여) / 동의생리병리학회지 / 대한동의병리학회 / 201108
    • 이중에너지컴퓨터단층촬영을 이용한 통풍의 진단 / 공동(참여) / 대한류마티스학회지 / 대한류마티스학회 / 201106
    • 파골세포 분화에 목향 물 추출물의 효과 / 공동(제1저자) / 동의생리병리학회지 / 대한동의병리학회 / 201106
    • 파골세포의 분화와 뼈 흡수에 천남성의 억제 효과 / 공동(제1저자) / 동의생리병리학회지 / 대한동의병리학회 / 201102
    • 백출의 파골세포 분화에 미치는 영향 / 공동(참여) / 동의생리병리학회지 / 대한동의병리학회 / 201102
    • Churg-Strauss 증후군 환자에서 재발성 장 천공이 발생한 1예 / 공동(교신) / 대한류마티스학회지 / 대한류마티스학회 / 201009
    • Candida arthritis after arthroscopic arthroplasty in a patient without predisposing factors / 공동(교신) / The open Rheumatology Journal / Rheumatology Journal / 201003
    • 염증성 골 소실 질환에서 범-Jak 억제제인 Pyridone 6의 골 흡수 억제 효과 / 공동(참여) / 대한골대사학회지 / 대한골대사학회 / 201003
    • Inhibition of osteoclast differentiation and bone resorption by rotenone, through down-regulation of RANKL-induced c-Fos and NFATc1 expression / 공동(참여) / Bone / ELSEVIER SCIENCE INC / 201003
    • Articular Cartilage Imaging by the Use of Phase-Contrast Tomography in a Collagen-Induced Arthritis Mouse Model / 공동(참여) / ACADEMIC RADIOLOGY / ELSEVIER SCIENCE INC / 201002
    • 파골세포 분화에 육종용 추출물의 효과 / 공동(제1저자) / 원광의과학회지 / 원광의과학회 / 200912
    • GM-CSF Regulates Fusion of Mononuclear Osteoclasts into Bone-Resorbing Osteoclasts by Activating the Ras/ERK Pathway / 공동(제1저자) / JOURNAL OF IMMUNOLOGY / AMER ASSOC IMMUNOLOGISTS / 200909
    • 베체트 증후군 환자에서 dapsone에 의해 발생한 중증의 DRESS 증후군 1예 / 공동(교신) / 대한 류마티스학회지 / 대한류마티스학회 / 200909
    • 파골세포 분화에서 토사자 물 추출물의 효과 / 공동(참여) / 동의생리병리학회지 / 대한동의병리학회 / 200908
    • Risedronate Directly Inhibits Osteoclast Differentiation and Inflammatory Bone Loss / 공동(참여) / BIOLOGICAL & PHARMACEUTICAL BULLETIN / PHARMACEUTICAL SOC JAPAN / 200907
    • 두충의 물 추출물이 파골세포의 분화에 미치는 영향 / 공동(참여) / 동의생리병리학회지 / 대한동의병리학회 / 200906
    • 골흡수에 M-CSF의효과 / 공동(참여) / 대한골대사학회지 / 대한골대사학회 / 200903
    • Pyridone 6, A Pan-Janus-Activated Kinase Inhibitor, Suppresses Osteoclast Formation and Bone Resorption through Down-Regulation of Receptor Activator of Nuclear Factor-kappa B (NF-kappa B) Ligand (RANKL)-Induced c-Fos and Nuclear Factor of Activated T Cells (NFAT) c1 Expression / 공동(참여) / BIOLOGICAL & PHARMACEUTICAL BULLETIN / PHARMACEUTICAL SOC JAPAN / 200901
    • Jak2 억제제인 AG490이 뼈파괴세포 (Osteoclast)의 분화에 미치는 영향 Effect of Jak2 Inhibitor AG490 on Osteoclast Differentiation / 공동(참여) / 대한해부학회지 / 대한해부학회 / 200812
    • 파골세포에 대한 커큐민의 효과 / 공동(참여) / 동의생리병리학회 / 대한동의생리병리학회 / 200812
    • Proteasome inhibitors induce osteoclast survival by activating the Akt pathway. / 단독 / Biochemical and biophysical research communications / academic press / 200812
    • Micro-CT Imaging with a Hepatocyte-selective Contrast Agent for Detecting Liver Metastasis in Living Mice / 공동(참여) / ACADEMIC RADIOLOGY / 미국 / 200810
    • Eupatilin inhibits H2O2-induced apoptotic cell death through inhibition of mitogen-activated protein kinases and nuclear factor-κB / 공동(교신) / Food and Chemical Toxicology / 미국 / 200806
    • Use of complementary and alternative medicine by rheumatoid arthritis patients in Korea / 공동(제1저자) / Clinical Rheumatology / Clinical Rheumatology / 200801